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| Knowhow offering | |
| Title | Process for Preparation of Copolymer-1-used in the treatment of multiple sclerosis |
| Knowhow is available for | Process for synthesis of CoPolymer1 and its pharmaceutically acceptable salts |
| Summary | A novel process using readily available raw materials, for the synthesis of Copolymer-1 and its pharmaceutically acceptable salts is described here. The process uses a polymer bound catalyst as an initiator (which requires 10X less catalyst concentration than conventional systems). The resulting polymer has a narrow molecular weight distribution, with m.wt can be tailored to be in the range of 8-19KDa. Copolymer-1 could be injected subcutaneously, intra-peritoneally, intravenously, intramuscularly for the treatment of multiple sclerosis. |
| Advantages | • A simple, cost-effective process using easily available raw materials • Yields a product with high degree of purity (without requiring additional steps of separation, purification etc.) • Molecular weight can be tailored to be in the range of 8-19KDa (hence overcoming toxicity issues; m. wt of over 20 KDa are known to be toxic)- with excellent control over the m. wt distribution • High purity levels - almost no acid residues (less than 1% ) |
| Knowhow is listed under following categories | |
| Knowhow from | CSIR-NCL, Pune |
| Scientific/ engineering subject areas | Chemical sciences & engineering ; Others |
| Investor interest categories | Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies |
| Industries | Pharmaceuticals, Bulk Drugs, Formulations ; Others |
| Customer categories and nature of business | Businesses and other industries (B2B) ; Others |
| Technology readiness levels | TRL B: Proof-of-concept demonstrated in lab scale |
Year of development | 2006 |
| Whether patents are part of this offering ? | Yes |
| Related documents: | |
| Published Patents | |
| Write- ups and marketing documents | |
| Database reference | |
| Database record number | 20130929110322 |
| Date of upload | 30 / Sep / 2013 |
| Date of update | 4 / Oct / 2013 |
| URL to site when communicating about this knowhow | http://nclinnovations.org/khdb/viewrecord.php?recordno=20130929110322 |
| Request for this technology | Click here for Request Form |
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